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Inform your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegalEach mL of SIMBRINZA (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2% contains: Active ingredients: brinzolamide 10 mg, brimonidine tartrate 2 mg (equivalent to 1.32 mg as brimonidine free base); Preservative: benzalkonium chloride 0.03 mg; Inactive ingredients: propylene glycol, carbomer 974P, boric acid, mannitol, sodium chloride, tyloxapol and purified water. Hydrochloric acid and/or sodium hydroxide may be added to adjust pH.Tell your doctor if you are taking any medicines, including those bought over-the-counter and herbal medicines, before you start treatment with Diclofenac Sodium EC. Similarly, check with your doctor or pharmacist before you take any new medicines while you are taking Diclofenac Sodium EC. Diclofenac Sodium EC may increase the blood levels of the following medicines: - lithium - digoxin - methotrexate. People taking Diclofenac Sodium EC with any of the above should be closely monitored by their doctor. There may be an increased risk of bleeding if Diclofenac Sodium EC is taken with blood-thinning or anti-clotting medicines (anticoagulants) such as warfarin. People taking Diclofenac Sodium EC with an anticoagulant should be closely monitored by their doctor. There may be an increased risk of side effects such as stomach irritation if Diclofenac Sodium EC is taken with corticosteroids such as prednisolone. Diclofenac Sodium EC should not be taken with any other NSAID, eg ibuprofen, as this increases the risk of side effects, particularly on the gut. Ciclosporin may increase the blood level of Diclofenac Sodium EC, and your doctor may prescribe a lower than normal dose of diclofenac if you are taking ciclosporin. There may be an increased risk of side effects on the kidneys if Diclofenac Sodium EC is taken with any of the following medicines: - ciclosporin - ACE inhibitors, eg enalapril - diuretics, eg frusemide (furosemide). Diclofenac Sodium EC may reduce the blood pressure lowering effects of diuretics such as frusemide (furosemide). There may potentially be an increased risk of seizures if Diclofenac Sodium EC is taken together with quinolone antibiotics such as ciprofloxacin.

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Brinzolamide has a molecular weight of 383.5. It is a white powder, which is insoluble in water, very soluble in methanol and soluble in ethanol.

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Other drugs that interfere with coagulation, including aspirin and other nonsteroidal anti-inflammatory medications, should be avoided when using SSRIs and SNRIs.

7. Gutierrez F, Navarro A, Padilla S, et al. "Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring." Clin Infect Dis 41 (2005): 1648-53

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